Science Journal Evidence – Toxic PEGs and Nanoparticles in COVID-19 Vaccines Responsible for Deaths and Adverse Reactions.
Interdisciplinary Sciences: Computational Life Sciences Published in June 2021; 13(2):344-347 Science Journals.
Evolve to Ecology note to reader -Strangely never made it to the main stream newspapers.
Are the Allergic Reactions of COVID-19 Vaccines Caused by mRNA Constructs or Nanocarriers? Immunological Insights. Interdisciplinary Sciences: Computational Life Sciences
Excerpt – ”The Food and Drug Administration (FDA) has recently authorized the two messenger RNA (mRNA) vaccines BNT162b2 and mRNA-1273 for emergency use against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing the COVID-19 coronavirus disease. BNT162b2 and mRNA-1273 vaccines were developed by Pfizer-BioNTech and Moderna, respectively, in 2020. The United Kingdom, Bahrain, Canada, Mexico, United States, Singapore, Oman, Saudi Arabia, Kuwait, and European Union began their vaccination programs with the BNT162b2 vaccine, while the United States and Canada also started the mRNA-1273 vaccination program in mid December 2020. On 28th December 2020, studies reported severe allergic reactions in people who received the BNT162b2, and few people who received the mRNA-1273 vaccine. Authors of the letter thus attempt to explore possible causes of anaphylaxis following COVID-19 vaccination. ‘
In the last 2 weeks, we read about the components of these two mRNA vaccines from different media resources. Briefly, the BNT162b2 vaccine contains the spike glycoprotein of SARS-CoV-2 coding mRNA, 2 [polyethylene glycol (PEG)-2000]-N, N-di-tetradecyl acetamide, 1, 2-distearoylsn-glycero-3-phosphocholine, cholesterol, (4-hydroxybutyl) azanediyl) bis (hexane-6, 1-diyl) bis (2-hexyldecanoate), potassium chloride, monobasic potassium phosphate, sodium chloride, dibasic sodium phosphate dehydrate, and sucrose. COVID-19 patients or volunteers (age>16) who received BNT162b2 vaccination at 21-day intervals of two dosages (30 μg/dose) attained 95% protection (ClinicalTrials.gov No: NCT04368728) against SARS-CoV-2[1].
Likewise, mRNA-1273 vaccine components include the spike glycoprotein of SARS-CoV-2 coding mRNA, PEG 2000 dimyristoyl glycerol, 1,2-distearoyl-sn-glycero3-phosphocholine, cholesterol, SM-102, tromethamine, tromethamine hydrochloride, acetic acid, sodium acetate, and sucrose.
Vaccinated COVID-19 patients or volunteers (age>18) with mRNA-1273 (2×100 μg/dose) in 28 days of interval acquired 94.1% protection (ClinicalTrials.gov No: NCT04470427) against SARS-CoV-2 [2]. The incidence of serious adverse effects of these mRNA vaccines was reported low but included mild-to-moderate pain at the injection site, fatigue, and headache. Both candidate vaccines use PEGlyated lipid nanoparticles as a carrier for vaccine delivery, which is administered through intramuscular injection to the patients and volunteers as well.
Evolve to Ecology note to reader– ”PEG’s are synthetic chemicals that may be contaminated by the presence of 1,4-dioxane, a chemical that the U.S. government has identified as a probable human carcinogen [1] [3] [2]. Exposure to PEG’s and trace amounts of 1,4-dioxne can lead to a number of health concerns”. Source
Evolve to Ecology note to reader– ‘Health and Environmental Hazards
Depending on manufacturing processes, PEGs may be contaminated with measurable amounts of ethylene oxide and 1,4-dioxane. i The International Agency for Research on Cancer classifies ethylene oxide as a known human carcinogen and 1,4-dioxane as a possible human carcinogen. Ethylene oxide can also harm the nervous system…. While carcinogenic contaminants are the primary concern, PEG compounds themselves show some evidence of genotoxicity vi,vii and if used on broken skin can cause irritation and systemic toxicity. viii The industry panel that reviews the safety of cosmetics ingredients concluded that some PEG compounds are not safe for use on damaged skin (although the assessment generally approved of the use of these chemicals in cosmetics). ix Also, PEG functions as a “penetration enhancer,” increasing the permeability of the skin to allow greater absorption of the product — including harmful ingredients. Source David Suzuki.org
Evolve to Ecology note to reader – ”Polyethylene glycol (PEG) is present in a variety of products. Little is known regarding the accumulation of high-molecular-weight PEGs or the long-term effects resulting from PEG accumulation in certain tissues, especially the choroid plexus. We evaluated the toxicity of high-molecular-weight PEGs administered to Sprague Dawley rats. Groups of 12 rats per sex were administered subcutaneous injections of 20, 40, or 60 kDa PEG or intravenous injections of 60 kDa PEG at 100 mg PEG/kg body weight/injection once a week for 24 weeks. A significant decrease in triglycerides occurred in the 60 kDa PEG groups. PEG treatment led to a molecular-weight-related increase in PEG in plasma and a low level of PEG in cerebrospinal fluid. PEG was excreted in urine and faeces, with a molecular-weight-related decrease in the urinary excretion. A higher prevalence of anti-PEG IgM was observed in PEG groups; anti-PEG IgG was not detected. PEG treatment produced a molecular-weight-related increase in vacuolation in the spleen, lymph nodes, lungs, and ovaries/testes, without an inflammatory response.
Evolve to Ecology note to readers– ”Vacuolization refers to the state or the process of forming vacuoles. The vacuoles may form inside or adjacent to the cells. 1. There are many instances in which vacuoles form. One of which is the neurodegenerative diseases in humans and animals caused by prions. Read Evolve to Ecology article on the connection between the jab and Prion’s Disease- Creutzfeldt-Jakob disease– CJD appears to be caused by an abnormal infectious protein called a prion. These prions accumulate at high levels in the brain and cause irreversible damage to nerve cells. While the abnormal prions are technically infectious, they’re very different from viruses and bacteria.
Evolve to Ecology note to reader- ”Mast cell infiltration at the application site was noted in all PEG-treated groups. These data indicate that subcutaneous and intravenous exposure to high-molecular-weight PEGs produces anti-PEG IgM antibody responses and tissue vacuolation without inflammation.”- Source For release till 2023- Toxicol Letters. 2022 Apr 15;359:22-30. doi: 10.1016/j.toxlet.2022.01.011. Epub 2022 Jan 29. Toxicity of high-molecular-weight polyethylene glycols in Sprague Dawley rats
(Jia-Long Fang et al).
Are the Allergic Reactions of COVID-19 Vaccines Caused by mRNA Constructs or Nanocarriers? Immunological Insights. Interdisciplinary Sciences: Computational Life Sciences –
excerpt continues….
PEG
The demographic and clinical characteristics of the mRNA-1273 vaccine included participants (0.6–4.9%) having a history of chronic lung disease, cardiac disease, severe obesity, diabetes, liver disease, and human immunodeficiency virus infection. Moreover, the clinical trials
of the BNT162b2 vaccine were conducted with a random selection of participants. On 28th December 2020, Banerji et al. [3] reported severe allergic reactions in some people
who received the BNT162b2, and fewer people who received the mRNA-1273 vaccine. In addition, Castells and Phillips [4] noted that severe anaphylaxis reaction was observed
in health care workers within 24 h after vaccination in the United Kingdom and Boston, United States [5]. Thus, the National center for immunization and respiratory diseases (NCIRD), Centers for disease control and prevention (CDC) advised health authorities of all countries to exclude anyone with a history of a severe allergic reaction associated with one of the vaccine components, especially PEG and PEG derivatives like polysorbates [6, 7].
Notably, allergens are mostly the proteins or glycoproteins or excipients present in the therapeutic molecules (e.g., vaccines) that promote or stimulate allergen-specific antibodies (i.e., immunoglobulins type E or IgE) in the human body [8]. These allergens react with IgE and cause allergic inflammatory responses. The crosslinking of IgE antibodies that are bound to the Fc epsilon RI (high-afnity IgE receptor) on the basophils and mast cells triggers degranulation in a short period. It results in the release of inflammatory mediators, namely histamine, prostaglandins and leukotrienes, proteases (G-protein-coupled receptors), and
pro-inflammatory cytokines; and observation of major allergic symptoms (e.g., nausea, vomiting, reddening, rashes, laryngeal edema, wheezing, tachycardia, hypotension, and cardiovascular collapse) [8].However, scientific personnel and medical professionals need to determine and understand the possible cause of allergic reactions, whether it by antigenic fragments or epitope (i.e., translated spike glycoprotein fragments) or excipients or stabilizer (PEG) in the vaccine molecules.
Evolve to Ecology note to reader-Remember how for this particular gene therapy, misleadingly called a vaccine, that a person will not be classified as vaccinated until 14 days after administration of the ”jab”, when in the history of vaccination has that ever been a new rule before?
Are the Allergic Reactions of COVID-19 Vaccines Caused by mRNA Constructs or Nanocarriers? Immunological Insights. Interdisciplinary Sciences: Computational Life Sciences –
excerpt continues to conclusion….
Further, the cohort study by the University of Oxford reported that two mRNA vaccines (BNT162b2 and mRNA1273) and the AstraZeneca vaccine possibly cause cerebral venous thrombosis (i.e., anaphylaxis reaction) after 14 days of vaccination [19]. The mechanism of action was not reported in the article but there is a chance that spike proteins may elicit anaphylaxis reaction because of the major similarity of these vaccines is the presence of “spike protein immunogen”. At present, vaccination programs have been initiated concurrently against COVID-19, but the debate is still going about the adverse effects and safety concerns raised by the vaccine. Moreover, the allergic reactions of the participants need to be identified or screened frequently by questionnaires and IgE testing before and after vaccination to monitor unpleasant adverse effects of the vaccine. In this concern, promising research outputs are needed to confirm the safety of the currently formulated mRNA vaccines.
Evolve to Ecology Conclusion
There has been scientific mounting evidence in the science journals, from doctors and nurses, from OpenVAERS Vaers Adverse events data which should only reflect 1 percent of the under reported events, if this is the case, then these numbers are beyond critical cause for concern, the day this article is posted, the latest data reads a staggering 2,267,391 Reports of adverse events, 30,347 COVID Vaccine Reported Deaths / 39,962 Total Reported Deaths. There are probably many deaths that are not connected to the vaccine that are classed as something else. There are 173,449 Total COVID Vaccine Reported Hospitalizations/256,857 Total Reported Hospitalizations and 1,385,398 COVID Vaccine Adverse Event Reports.
EU EudraVigilance as of 30th of July, 2022, 76,789 deaths and 6,089,773 adverse effects were reported between the US and Europe due to COVID gene therapies. Historically, drug harm surveillance systems have been shown to only report 1% of actual adverse events from vaccines. 🇪🇺 IN EUROPE: EudraVigilance 46,999 deaths and 4,731,833 injuries (2,143,362 serious).
Yellow Card UK data above including new data on Child deaths in the UK.
4,229 INJURIES/DEATHS TO CHILDREN- UK reported on 29/06/22
UK Adverse events
•2,207 Deaths
•1,503,321 injuries
• 4,229 injuries and deaths in Children
• 50,677 Injuries and deaths after ‘boosters’.
There is no exact total to extrapolate entire vaccine injured global population as most countries do not report these adverse reactions or deaths, but from this insight, we can see already that that millions have been killed and permanently injured due to effects of the experimental gene therapy jab name COVID-19 vaccination. This particular article is highlighting the dangers of some of the ingredients including PEG and nanoparticles, although some of the science journal excerpts still play down the toxicity of PEGs and the inflammation aspects, no where is it mentioned that PEGs are also carcinogens, like dioxins. We also know that the human foetal tissue MRC-5 cell lines were oncogenic, which is why there has been an explosion in cancer and returning cancer cases in the vaccinated population. PEG has been shown from experiments in lab rats to cause molecular-weight-related increase in vacuolation in the spleen, lymph nodes, lungs, and ovaries/testes in these animals, vacuolation is also connected to Prion’s Disease- Creutzfeldt-Jakob disease, so if PEG and nanoparticles can pass the blood brain barrier and be found in the body’s organs, cerebral spinal fluid and the brain, this may explain why there have been vacuolation in the brain causing subacute spongiform encephalopathy, also called Mad Cows disease or Prion’s Disease- Creutzfeldt-Jakob disease.
In an article published last year by Dr. J.Bart Classen in the Journal of Microbiology & Infectious Diseases, it is explained that in the Covid Jab ingredients, ”Zinc ions have been shown to cause the transformation of TDP-43 to its pathologic prion configuration. The folding of TDP-43 and FUS into their pathologic prion confirmations is known to cause ALS, front temporal lobar degeneration, Alzheimer’s disease and other neurological degenerative diseases. The enclosed finding as well as additional potential risks leads the author to believe that regulatory approval of the RNA based vaccines for SARS-CoV-2 was premature and that the vaccine may cause much more harm than benefit. ” –J. Bart Classen, MD. 2021; 5(1): 1-3. Journal of Microbiology & Infectious Diseases.
The research uncovered that, indeed, a plausible mechanism for mRNA Covid-19-induced prion formation exists, namely, “the folding of TDP-43 and FUS into their pathologic prion confirmations is known to cause ALS, front temporal lobar degeneration, Alzheimer’s disease and other neurological degenerative diseases.”
The study points that previous research has been done that indicates there is a link between COVID-19 vaccines and prion disease:
“Finally, others working in the field have published additional support that COVID-19 vaccines could potentially induce prion disease. Authors [18] found prion related sequences in the COVID-19 spike protein which were not found in related coronaviruses. Others [19] have reported a case of prion disease, Creutzfeldt-Jakob disease, initially occurring in a man with COVID-19….. “Approving a vaccine, utilizing novel RNA technology without extensive testing is extremely dangerous. The vaccine could be a bioweapon and even more dangerous than the original infection.”
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Evolve to Ecology
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